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A mixture of purified porcine gangliosides; found in all cells but at particularly high levels in the brain; typically contain stearic acid as the fatty acyl chain; modulate intra- and inter-cell signaling and regulate receptor function; involved in developmental processes; implicated in tumorigenesis
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This gene encodes complement protein C3 which plays a central role in the classical alternative and lectin activation pathways of the complement system The encoded preproprotein undergoes a multi-step processing to generate various functional peptides Mice deficient in the encoded protein fail to clear bacteria from the blood stream upon infection display diminished airway hyperresponsiveness and lung eosinophilia upon allergen-induced pulmonary allergy and develop severe lung injury after deposition of IgG immune complexes Deficiency of the homolog of the encoded protein in humans was found to be associated with increased susceptibility to infections age-related macular degeneration and atypical hemolytic uremic syndrome
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Complement C3/C3a protein activates the complement system playing a central role in both classical and alternative pathways C3b binds covalently to cell surface carbohydrates or immune aggregates while C3a acts as an inflammatory mediator inducing neutrophil chemoattraction and promoting smooth muscle contraction increased vascular permeability and histamine release The shorter isoform of C3a stimulates B-cells Complement C3/C3a Protein Mouse is the recombinant mouse-derived Complement C3/C3a protein expressed by E coli with tag free
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This gene encodes a member of the S1 or chymotrypsin family of serine peptidases This protease catalyzes the cleavage of factor B the rate-limiting step of the alternative pathway of complement activation This protein also functions as an adipokine a cell signaling protein secreted by adipocytes which regulates insulin secretion in mice Mutations in this gene underlie complement factor D deficiency which is associated with recurrent bacterial meningitis infections in human patients Alternative splicing of this gene results in multiple transcript variants At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease
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The R-PLEX Human Complement C3a Assay from Meso Scale Discovery is a multiplex immunoassay that measures C3a in human serum plasma and other biological fluids This assay utilizes MSD s electrochemiluminescent detection technology and provides high sensitivity a broad dynamic range and requires a low sample volume The C3a assay measures complement activation and can be used to monitor inflammation and autoimmune diseases This quantitative assay has high reproducibility and requires 2 5 hours to complete
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